Information about UNICAP

Composition:
Each Tablet Contains: Captopril 50 mg, Hydrochlorothiazide 25 mg.
Pharmacokinetics:
Captopril:
Following oral administration of therapeutic doses of Captopril, rapid absorption occurs with peak blood levels at about one hour.
The presence of food in the gastrointestinal tract reduces absorption by about 30 to 40 percent captopril therefore should be given one hour before meals.
In a 24 hour period, over 95 percent of the absorbed dose is eliminated in the urine, 40 to 50 percent is unchanged drug.
Approximately 25 to 30 percent of the circulating drug is bound to plasma proteins.
The apparent elimination half-life for total radioactivity in blood is probably less than 3 hours.
In patients with renal impairment, however, retention of captopril occurs.
Hydrochlorothiazide:
After oral use diuresis begins within 2 hours, peaks in about 4 hours and lasts about 6 to 12 hours.
Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney.
When plasma levels have been followed for at least 24 hours, the plasma half-life has been observed to vary between 5.6 and 14.8 hours.
At least 61% of the oral dose is eliminated unchanged within 24 hours. Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.
Indications:
Captopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension).
Contraindications:
• Hypersensitivity to either component or sulfonamides.
• History of hereditary or idiopathic angioedema.
• Coadministration of neprilysin inhibitors (e.g, sacubitril) with ACE inhibitors may increase angioedema risk, do not administer ACE inhibitors within 36 hr of switching to or from sacubitril/valsartan.
• Bilateral renal artery stenosis or anuria.
• Do not coadminister with aliskiren in patients with diabetes.
Side Effects:
More common:
• Black, tarry stools.
• Chest pain.
• Chills.
• Cough.
• Fever.
• Painful or difficult urination.
• Shortness of breath.
• Sore throat.
• Sores, ulcers, or white spots on lips or in mouth.
• Swollen glands.
• Unusual bleeding or bruising.
• Unusual tiredness or weakness.
• Difficulty in moving.
• Itching skin.
• Muscle pain or stiffness.
• Pain in joints.
• Rash.
Less common:
• Blurred vision.
• Cloudy urine.
• Confusion.
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly.
• Fast, pounding, or irregular heartbeat or pulse.
• Sweating.
• Change in taste.
• loss of taste.
Storage Conditions:
Don’t Store Above 30°C. A way from Moisture.
Packaging:
Carton Pack of 30 tablets.