Information about CAPOTEN UNI

Composition:
Each Tablet Contains: Captopril 25 mg or 50 mg.
Pharmacokinetics:
Following oral administration of therapeutic doses of Captopril, rapid absorption occurs with peak blood levels at about one hour. 
The presence of food in the gastrointestinal tract reduces absorption by about 30 to 40 percent captopril therefore should be given one hour before meals. 
In a 24-hour period, over 95 percent of the absorbed dose is eliminated in the urine, 40 to 50 percent is unchanged drug.
Approximately 25 to 30 percent of the circulating drug is bound to plasma proteins. 
The apparent elimination half-life for total radioactivity in blood is probably less than 3 hours. In patients with renal impairment, however, retention of captopril occurs.
Indications:
• Hypertension.
• Heart Failure.
• Left Ventricular Dysfunction After Myocardial Infarction.
• Diabetic nephropathy.
Contraindications:
• In patients who are hypersensitive to this product or any other angiotensin-converting enzyme inhibitor (e.g. a patient who has experienced angioedema during therapy with any other ACE inhibitor).
• Co-administration with Aliskiren in patients with diabetes.
Adverse Reactions:
• Renal: renal insufficiency, renal failure, nephrotic syndrome, polyuria, oliguria, and urinary frequency.
• Hematologic: Neutropenia/agranulocytosis has occurred. Cases of anemia, thrombocytopenia, and pancytopenia have been reported.
• Dermatologic: Rash, often with pruritus, and sometimes with fever, arthralgia, and eosinophilia.
• Cardiovascular: Tachycardia, chest pain, palpitations, Angina pectoris, myocardial infarction, Raynaud’s syndrome, and congestive heart failure.
• Dysgeusia: diminution or loss of taste perception. Weight loss may be associated with the loss of taste.
• Angioedema: Angioedema involving the extremities, face, lips, mucous membranes, tongue, glottis or larynx has been reported. 
• Cough: Cough has been reported in patients treated with captopril in clinical trials.
• The following have been reported in about 0.5% to 2% of patients in controlled trials: gastric irritation, abdominal pain, nausea, vomiting, diarrhea, anorexia, constipation, aphthous ulcers, peptic ulcer, dizziness, headache, malaise, fatigue, insomnia, dry mouth, dyspnea, alopecia, paresthesia’s.
Package:
Carton Pack of 20 Tablets for both strengths 25 & 50 mg.
Storage Conditions:
Don’t Store above 30°C, Away from Light & Moisture.