Information about DILANACIN UNI

Composition:
Each tablet contains: 0.25 mg Digoxin.
Pharmacokinetics:
Bioavailability: 60-80% (tablet).
Onset: 0.5-2 hr (PO) for initial effect and 2-6 hr for maximal effect.
Duration: 3-4 days.
Peak serum time: 1-3 hr (PO).
Protein bound: 20-25%.
Vd: 6-7 L/kg.
Metabolism: Metabolized by liver.
Half-life: 1-3 days.
Excretion: Urine: 57-80%, feces: 9-13% includes bile.
Indications:
•    Heart Failure in Adults.
•    Heart Failure in Pediatric Patients.
•    Atrial Fibrillation in Adults.
Contraindications:
Digoxin Tablets are contraindicated in patients with:
•    Ventricular fibrillation.
•    Known hypersensitivity to digoxin (reactions seen include unexplained rash, swelling of the mouth, lips or throat or a difficulty in breathing).
•    A hypersensitivity reaction to other digitalis preparations usually constitutes a contraindication to digoxin.
Adverse Reactions:
•    Cardiac arrhythmias.
•    Digoxin Toxicity.
Storage Conditions:
Store below 30°C away from moisture.
Packaging:
Carton pack of 50 tablets.