Information about MEDERGOT - UNI

Composition:
Each Sugar Coated Tablet contains: 1 mg Ergotamine tartrate + 100 mg Caffeine.
Clinical pharmacology:
Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. The compound also has the properties of serotonin antagonism. In comparison to hydrogenated ergotamine, the adrenergic blocking actions are less pronounced and vasoconstrictive actions are greater.
Caffeine, also a cranial vasoconstrictor, is added to further enhance the vasoconstrictive effect without the necessity of increasing ergotamine dosage.
Indications:
Ergotamine tartrate and caffeine tablets are indicated as therapy to abort or prevent vascular headache; e.g., migraine, migraine variants or so-called “histaminic cephalalgia.”
Pregnancy:
Pregnancy Category X
Dosage and Administration:
For the best results, dosage should start at the first sign of an attack.
Adults: Take 2 tablets at the start of attack; 1 additional tablet every ½ hour, if needed for full relief (maximum 6 tablets per attack, 10 per week).
Maximum Adult Dosage: 
Total daily dose for any one attack should not exceed 6 tablets. Total weekly dosage should not exceed 10 tablets. Ergotamine tartrate and caffeine tablets should not be used for chronic daily administration. 
Storage conditions: 
Don’t store above 30°C.
Packaging:
Carton pack of 20 Sugar coated tablets.