Bantrin
Bantrin Tablets , Bantrin Oral suspension
Composition:
Tablets :Each tablet contains 360 mg of pyrantel pamoate equivalent to 125 mg of pyrantel base
Oral Suspension :Each 5ml contains : Pyrantel base 250 mg as (Pyrantel pamoate)
Excipients:
For Tablets :
Alginic acid, corn starch, FD&C yellow No.6 , Magnesium stearate, Sodium Lauryl sulfate.
For Oral Suspension :
Citric acid anhydrous, Glycerol, polysorbate 80, Polyvinylpyrolidone, sodium hydroxide, sorbitol solution, magnesium aluminium silicate, lecithin, sodium benzoate, Flavour caramel.
Mechanism of action:
The anthelmintic action is probably due to the neuromuscular blocking property of the drug, which causes paralysis and release of their hold to the intestinal wall. Expulsionof the parasites from the GI tract occurs by normal peristalsis .
Pharmacokinetics:
Absorption: pyrantel pamoate is partially absorbed after an oral dose. Peak levels are reached in 13- hours.
Excretion: greater than 50% of administered drug are excreted in feces as the unchanged form, whereas only 7% or less of the dose is found in urine as the unchanged form of the drug and its metabolites.
Indications:
Pyrantel pamoate has demonstrated anthelmintic activity :
• Enterobiusvermicularis(pinworm).
• Ascarislumbricoides(roundworm).
• Ancylostomaduodenale(hookworm).
• Necatoramericanus(American hookworm).
• Trichostrongyluscolubriformis and orientalis (roundworm).
Contraindications:
Hypersensitivity to any of the ingredients, intestinal obstruction, hepatic disease.
Side effects:
Abdominal cramps, nausea, vomiting, diarrhea, headache, dizziness.
Drug interactions:
There are no drug interactions associated with Pyrantel products.
Pregnancy and lactation:
Pyrantel is poorly absorbed from the GI tract. There are no well controlled studies of pyrantel use in pregnant women. Use pyrantel with caution during pregnancy. Some experts suggest that single-dose pyrantel therapy may be given to pregnant women. Pregnant women should not take pyrantel unless directed by a doctor.
There are no data regarding the presence of pyrantel in breast milk. Pyrantel is poorly absorbed from the GI tract; therefore, excretion into breast milk may be minimal. Some experts suggest single-dose pyrantel therapy may be given to breast-feeding women. Breast-feeding infant exposure may be minimized if the drug is taken just before the longest sleep interval for the infant
Dosage and administration Dosage :
Take Bantrin only according to directions and do not exceed the recommended dosage unless directed by a doctor. Medication should only be taken onetime as a single dose; do not repeat treatment unless directed by a doctor. When one individual in a house hold has pinworms, the entire household should be treated unless otherwise advised . If any worms other than pinworms are present before or after treatment, consult a doctor. If any symptoms or pinworms are still present after treatment, consult a doctor. This product can be taken any time of day, with or without meals. It may be taken alone or with milk or fruit juice. Use of a laxative is not necessary prior to, during, or after medication.
Bantrin should not be used in children under 6 months of age because sufficient data are not available.
Adults and children 2 years to under 12 years of age: oral dosage is a single dose of 11 milligrams per kilogram, of body weight not to exceed 1 gram.
• For the treatment of enterobiasis (pinworm infection):
Children 2 years and older weighing 11 kg or more and Adolescents:
11 mg/kg base (Max: 1 g) PO as a single dose. Retreatment may be necessary after 14 to 21 days. Treatment of the entire household is11 mg/ kg base (Max: 1 g) PO as a single dose. Retreatment may be necessary after 14 to 21 days.
11 kg or under 2 years old :Do not use unless directed by a doctor. 11 to 16 kg:12/ tablet(125mg) or 2.5 ml(½ teaspoonful ).
17 to 28 kg :1 tablet (250 mg) or 5ml (1 teaspoonful ).
29 to 39 kg: 1 12/ tablets(375 mg) or 7.5 ml (1½ teaspoonfuls).
40 to 50 kg :2 tablets(500 mg) or 10 ml(2 teaspoonfuls ).
51 to 62 kg :2 12/ tablets(625 mg) or 12.5 ml (2½ teaspoonfuls ). 63 to 73 kg: 3 tablets(750 mg) or 15 ml(3 teaspoonfuls ).
74 to 84 kg: 3 12/ tablets(875 mg) or 17.5 ml(3½ teaspoonfuls). over 84 kg: 4 tablets(1000 mg) or 20 ml(4 teaspoonfuls ).
Children 2 years and older weighing less than 11 k t:
11 mg/kg base PO as a single dose. Retreatment may be necessary after 14 to 21 days. Treatment of the entire household is recommended. Consult physician and do not self-treat.
Infants† and Children 1 year t:
11 mg/kg base PO as a single dose. Retreatment may be necessary after 14 to 21 days. Treatment of the entire household is recommended. Consult physician and do not self-treat.
For the treatment of ascariasis:
Adults:
11 mg/kg base (Max: 1 g) PO once daily for 3 days as an alternative to albendazole or mebendazole.
Infants, Children, and Adolescents:
11 mg/kg base (Max: 1 g) PO once daily for 3 days as an alternative to albendazole or mebendazole.
• For the treatment of uncinariasis† (hookworm infection):
Adults:
11 mg/kg base (Max: 1 g) PO once daily for 3 days. Infants, Children, and Adolescents:
11 mg/kg base (Max: 1 g) PO once daily for 3 days.
• For the treatment of trichostrongyliasis†:
Adults:
11 mg/kg base (Max: 1 g) PO as a single dose.
Overdosage:
In case of accidental overdose, seek professional assistance.
Other information:
Many who have pinworms do not have symptoms. Nevertheless, many will experience itching in and around the rectal opening. The itching may be very annoying and continued scratching can cause an irritation in this area. The itching may be presented at night when sleeping. That is why restless sleep is sometimes a sign of pinworms, especially in children. It is important for you to realize that you should only treat with Pyrantel Pamoate if you have seen and identified the pinworms.
Pinworms look like tiny white threads. The female pinworm is about ½ long (the male pinworm is shorter). They live in the bowel. Usually, at night, the female travels to the rectal opening and lays eggs within the skin folds around the opening. This usually takes place within one to two hours after the child has been put to bed for the night. The stickgelatin-like substance in which the eggs (they are too small to see) are deposited and the movement of the female pinworm may cause annoying itching and possibly restless sleep.
The pinworm eggs normally survive for as long as three weeks. In that time, the pinworm egg may hatch and the pinworm will travel back within the rectal opening into the bowel. The pinworm reaches maturity in the bowel within two to six weeks and the life cycle repeats itself.
Scratching will cause pinworm eggs to stick to the fingers. Reinfection will result if the fingers are placed in the mouth. The eggs, which are too small to see, contaminate whatever they come in contact with: bed clothes, underwear, toys, hands, and food touched by contaminated hands. Even eggs floating in the air can be swallowed and cause infection.
Pinworms are highly contagious. Even the cleanest and most careful people can get them.
After treatment with Pyrantel Pamoate, there are some rules to follow
to try to prevent spreading to others and reinfection:
Wash hands and fingernails with soap often during the day, especially before eating and after using the toilet.
Wear tight underpants both day and night. Change them daily.
For several days after treatment, clean the bedroom floor by vacuuming or damp mopping. Avoid dry sweeping that may stir up dust.
After treatment, wash bed linens and night clothes (don>t shake them).
Keep the toilet seats clean.
Storage conditions:
- Tablets : Store at room temperature at 25°.
- Oral Suspension : store at 20° – 25° C. Do not freeze
Packaging :
- Tablets: pack of 6 tablets.
- Oral Suspension: glass bottle of 15 ml .