Petolytic
Serratiopeptidase
ECT , TAB (5,10 mg)
Composition :
Each Enteric-coated tablet of Petolytic contains 5 or 10mg Serratiopeptidase.
Pharmacodynamics:
- Petolytic an enzyme naturally occurring in silk worms for treatment of back pain .
- Petolytic improves the aggravated circulation in the inflammatory focus by breaking down abnormal products through the blood and lymphatic vessels.
- Petolytic accelerates the elimination of sputum, pus and hematoma by breaking down and liquefying mucous secretions and fibrin clots.
- Petolytic increase the concentration of antibiotics in the focus of infection and blood.
Petolytic is thought to work in three ways:
1. Anti-inflammatory: serratiopeptidase reduces swelling by the process of decreasing the amount of fluid in the tissues, thinning the fluid, and by facilitating the drainage of fluid. In addition, its enzyme activity dissolves dead tissue surrounding the injured area so that healing is accelerated.
2. Analgesic: it may help alleviate pain by inhibiting the release of pain-inducing amines like bradykinin from inflamed tissues.
3. Fibrinolytic/caseinolytic: it may be beneficial in atherosclerotic disease as it acts by breaking down fibrin and other dead or damaged tissue without harming living tissue. This could enable the dissolution of blood clots, and atherosclerotic plaques
Pharmacokinetics:
After oral administration, Petolytic is absorbed through the intestines and transported directly into the bloodstream.Its concentrations in plasma and lymph were dose dependent. peak plasma concentration was achieved 0.25–0.5 h after the dose and disappeared by 6 h. Petolytic is absorbed from the intestine, distributed to the inflammatory site via blood or lymph.
INDICATIONS:
Petolytic is successfully used in the treatment of:
- Inflammation after surgical operations and traumatic injuries.
- Inflammation of the following cases and symptoms:
- Otorhinolaryngology: sinusitis.
- Gynecology: Breast engorgement.
- Urology as cystitis and epididymitis.
- Dentistry and oral surgery: Pericoronitis of the wisdom teeth & alveolar abscess.
- Inadequate expectoration of sputum in the following diseases: Bronchitis bronchial asthma and pulmonary tuberculosis.
- Inadequate expectoration of sputum after anesthesia.
- Petolytic is being used in many clinical specialities for its anti-inflammatory, anti-edemic and analgesic effects.
CONTRAINDICATIONS:
Although, there are no known contraindication for Petolytic until now, the below mentioned precautions should be taken into consideration.
Caution should be taken when sensitivity to active ingredient occurs.
PRECAUTIONS:
Petolytic , should be given under careful observation to patients with blood coagulation abnormalities, severe hepatic and renal disturbances or under treatment with anticoagulants.
Side effects :
Petolytic , may occasionally cause gastrointestinal disturbances such as anorexia, nausea and gastric discomfort.
Petolytic may cause : stevens-johnson syndrome ,toxic epidermal necrolysis , anaphylactic shock symptoms, hepatitis and jaundice .
Administration should be discontinued when hypersensitivity symptoms such as skin eruption, appear.
Drug interactions:
There are no clinical studies reporting any drug interactions. If administered along with Warfarin, Clopidogrel or Aspirin as well as with other natural remedies such as garlic, fish oil and turmeric, there may be increased risk of bleeding or bruising.
DOSAGE &ADMINISTRATION:
Administrate one tablet three times daily after meal without chewing. Dosage may be increased according to the condition.
The dose which has been used in clinical studies and mentioned in drug monographs ranges from 10 mg to 60 mg per day. It has to be taken on an empty stomach or at least two hours after eating, and no food should be consumed for about half an hour after taking Serratiopeptidase.
How supplied : 20 enteric-coated tablet .