Information about Toricox
Toricox 60 mg, 90 mg, 120 mg Film-coated Tablets
Composition:
Each Toricox F.C. Tablet contains, either:
30 mg etoricoxib or
60 mg etoricoxib or
90 mg etoricoxib or
120 mg etoricoxib
Pharmacological Properties:
Etoricoxib isan anti-inflammatory, antirheumatic and non-steroidal product.
It is a member of the coxibs group.
Mechanism of action: Etoricoxib is an oral,selective cyclo-oxygenase-2 (COX-2) inhibitor within the clinical dose rang: (produced dose dependent inhibition of COX-2 without inhibition of COX-1 at doseup to 150 mg daily).
Etoricoxib does not inhibit gastric prostaglandin synthesis and has no effect on platelet function.
Indication:
Toricox is indicated for the symptomatic relief of osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis, and the pain signs of inflammation associated with acute gouty arthritis.
Side Effects:
The following undesirable effects were reported at an incidence greater than placebo inclinical trials in patients with OA, RA, chronic low back pain or ankylosing spondylitis treated with etoricoxib.
Gastroenteritis,upper respiratory infection and urinary infection are uncommon also anemia,leukopenia/ anaphylactoid reactions including shock are very rare. Edema /fluid retention are common, but appetite increase or decrease and weight gainare uncommon. Anxiety, depression, and mental acuity decreased are uncommon,but confusion and hallucination are very rare. Dizziness and headache arecommon, but dysgeusia, insomnia, paresthesia / hypesthesia and somnolence areuncommon. Also blurred vision, conjunctivitis, tinnitus and vertigo areuncommon.
Palpitationsare common, but atrial fibrillation, congestive heart failure, non-specific ECG changes, angina pectoris and myocardial infraction are uncommon.
Hypertension iscommon, but flushing, cerebrovascular accident and transient is chemic attack uncommon. Hypertensive crisis is very rare. Cough, dyspnea and epistaxis areuncommon and bronchospasm is very rare. Abdominal pain, flatulence, heartburn, diarrhea, dyspepsia, epigastria discomfort and nausea are common.
Dosage and Administrations:
Toricox is administered orally and may be taken withor without food. The onset of the effect may be faster when it is administered without food.
The recommended dose in:
-Osteoarthritis:( 60 mg once daily) “not to exceed 60 mg daily”.
-Rheumatoid arthritis: 90 mg once daily. (Not to exceed 90 mg daily).
-Acute gouty arthritis: 120 mg once daily (only for the acute symptomatic period“about 8 days”).
-Ankylosing spondylitis: 90 mg once daily.
Over dosage:
In clinical studies, administration of single doses of etoricoxib up to 500mg and multiple doses up to 150mg / day for 21 days did not result in significant toxicity. The most frequently observed adverse experiences of over dosage were consistent with the safety profile for etoricoxib (e.g. gastrointestinal, cardiorenal events).
In the event ofthe overdose, it is reasonable to employ the usual supportive measures, e.g.remove unabsorbed material from the GI tract, employ clinical monitoring, and institute supportive therapy, it is required.
Etoricoxib isnot dialyzable by hemodialysis; it is not known whether etoricoxib is dialysisby peritoneal dialysis.
Storage:
Store in the original package in order to protect from moisture
Keep it out of the reach of children.
Packing:
Packs of 10 & 20 Tablets for all strengths.